In Vs System 2PCG, players choose a main character, build a deck with exactly sixty cards, and attempt to KO the other player's main character in a game of superhero battles.

Vs System 2PCG is superficially similar to the original Vs. System collectible card game, but is a completely rebuilt game that takes some inspiration from the original. Combat has been streamlined, the turn structure is different, the resource system has been revamped, and the game is no longer collectible, with cards instead being released in a non-random format. A single box contains a full play-set of all cards.

Calling for backup! The second issue of the Earth 199999 Arc, Vs System 2PCG: MCU Heroes brings more of the heroes fans love. This 55 card expansion to Vs System 2PCG: The MCU Battles introduces Black Panther, Doctor Strange, Ant-Man, Scarlet-Witch, and more. Avengers Assemble!